低浓度HBsAg感染者乙肝5项标志物测定意义

Determination of Five Serological Markers of Low Level HBsAg Infectors

目的 :观察低浓度 HBs Ag感染者乙肝 5项标志物的模式特征。方法 :采用 EL ISA法测定了 38例 HBs Ag浓度在5μg/ L以下血清中乙肝病毒表面抗体 (抗 - HBs)、乙肝病毒核心抗体 (抗 - HBc)、乙肝病毒 e抗原及其抗体 (HBe Ag、抗 - HBe)。结果 :低浓度 HBs Ag感染者血清 5项 HBV标志有 8种表现模式 ,以“HBs Ag、抗 - HBc、抗 - HBe阳性 ,抗 - HBs、HBe Ag阴性”模式为主(6 5 .79% ) ,其次为“HBs Ag、抗 - HBc、HBe Ag阳性 ,抗 - HBs、抗 - HBe阴性”和“HBs Ag、抗 - HBc阳性 ,抗 - HBs、HBe Ag、抗 - HBe阴性”模式 (分别为 10 .5 3%和 7.89% ) ,HBs Ag和抗 - HBc同时阳性者 92 .11%。结论 :低浓度 HBs Ag感染者具有特殊的流行病学特点 ,提高 HBs Ag测定灵敏度具有重要意义。

Objective To observe the pattern features of 5 serological markers of low level HBsAg infectors.Methods Thirty-eight samples with HBsAg concentration equal to or lower than 5 μg/L were obtained using ELISA to detect HBsAg,anti-HBs, Anti-HBc,HBeAg and anti-HBe.Results Eight various patterns of the 5 serological markers were found in 38 samples with low level HBsAg, mainly 'positive for HBsAg,anti-HBc and anti-HBe, but negative for anti-HBs and HBeAg' (65.79 %), followed by 'positive for HBsAg,anti-HBc and HBeAg but negative for anti-HBs and anti-HBe', 'positive for HBsAg and anti-HBc but negative for anti-HBs, HBeAg and anti-HBe'(10.53 % and 7.89 % respectively),and HBsAg and anti-HBc were frequently present in their sera (92.11 %). Conclusion The low level HBsAg infectors have epidemiological characteristics in population and it is of significance in improving the sensitivity of HBsAg determination.