^(131)I治疗Graves病对外周血白细胞影响的研究

Study of the Effect of~ (131)I Treatment of Graves Disease on the Number of Peripheral Blood Leucocyte.

目的 探讨13 1I治疗Graves病对外周血白细胞的影响。方法 将接受13 1I治疗的Graves病患者按13 1I用量分组 ,于服13 1I前和服13 1I后做外周血白细胞测量 ,观察白细胞的变化。结果 13 1I治疗后第 4天白细胞总数、中性粒细胞、淋巴细胞的绝对值出现减少 ;中性粒细胞减少显著 (P <0 0 5 ,P <0 0 1) ,且与13 1I用量呈显著负相关 (P <0 0 5 )。白细胞减少者占 6 9 4% ;13 1I治疗后第 7天白细胞已回升至接近疗前水平。结论 13 1I治疗Graves病可使外周血白细胞尤其是中性粒细胞短时间内 (约 1周 )减少 ,减少程度与13 1I用量有关 ,一周后可恢复至接近疗前水平。13

Objective To study the effect of 131I treatment of Graves disease on the number of peripheral blood leucocytes.Methods The Graves disease patients were divided into groups according to the 131I dosage taken,peripheral blood leucocytes were measured before and after the taking of 131I.Results On the 4th day after taking 131I,the absolute value of leucocyte,neutrophil,Lymphocyte were decreased,the number of neutrophil was significantly decreased(P<0.05 or P<0.01),the number of neutrophil had significant negative relationship with the dosage of 131I(P<0.05).The rate of patients whose leucocytes decreased were 69.4%.The number of leucocytes were close to primary level on the 7th day after taking 131I.Conclusion 131I treatment of Graves disease can reduce the number of leucoctes,especially neutrophil,in a short time(about one week),it is related with the dosage of 131I.After a week,they can nearly return to the primary level.Some medicine which can increase the number of leucocytes should be used when the patient taking 131I.