肺泡巨噬细胞与香烟、矽尘共同培养产物对肺成纤维细胞生长的影响

THE EFFECT OF SILICA AND/OR CIGARETTE-TREATED ALVEOLAR MACROPHAGES ON THE CULTURE OF FIBROBLASTS

在体外培养条件下观察肺泡巨噬细胞(AM)与香烟及(或)矽尘共同培养后其产物对人胚肺成纤维细胞生长的影响。实验结果表明,在AM的培养液中加入香烟和矽尘,其培养物上清液能刺激人胚肺成纤维细胞生长,提示与矽尘接触的人如果吸烟可能促进矽肺发生。

The effects of silica and/or cigarette-treated rabbit alveolar macrophages ( AM ) on human embryo lung fibroblasts were studied in vitro. It was found that only the silica and cigarette-treated AM stimulated the proliferation of fibroblasts significantly ( P<0.05 ), indicating that smokers are more vulnerable to silicosis following the exposure to silica.