突发性聋患者血清同型半胱氨酸水平测定临床意义的探讨

Determination of level of the serum totalhomocysteine in patients with sudden deafness

目的 :探讨血清同型半胱氨酸水平与突发性聋发病的关系。方法 :收集突发性聋病人 31例 (32耳 ) ,男 16例 ,女 15例 ,年龄 18～ 70岁 ,用荧光偏振免疫发光法检测同型半胱氨酸水平 ,用氧消耗速率法、CHO氧化酶法、GPO- POD紫外光吸收试验法分别测定病人血清的血糖、胆固醇及甘油三脂含量。设 2 3例健康体检者为对照组 ,男 14人 ,女 9人 ,年龄 38～ 6 0岁 ,同法测定血清同型半胱氨酸、血糖、胆固醇及甘油三脂。结果 :突发性聋病人血清同型半胱氨酸水平(2 0 .6 6± 11.31μmol/ L)明显高于对照组 (11.30± 2 .6 0 μmol/ L) P <0 .0 5。血清中血糖、胆固醇及甘油三脂水平在两组间无明显差异。结论 :血清中同型半胱氨酸含量增高可能是突发性聋的独立危险发病因素之一。

Objective:To investigate the clinical significance of the serum totalhomocysteine on patients with sudden deafness.Method:The levels of totalhomocysteine,glucose,cholesterol and triglycerides were measured on 31 patients (16 males and 15 females,ranging in age from 18 to 70 years old)with sudden deafness(group A)and 23 normal subjects(14 males and 9 females,ranging in age from 38 to 60 years old)(group B).Result:The serum level of totalhomocysteine was 20 66±11 31μmol/L in group A,11 33±2 6μmol/L in group B(P<0.05)respectively.The serum levels of glucose,cholesterol and triglycerides were not different in group A and group B.Conclusion:The level of serum totalhomocysteine should be in relation with sudden deafness.