摘要
目的 :研究DDP诱发呕吐的胃肠道机制和止呕合剂对其的作用。方法 :记录 30只猫的呕吐发生率 ,并用生物化学分析法测定 5 -HT和NO含量。结果 :DDP增加了呕吐发生率 ,提高体内 5 -HT的含量 ,减少NO的含量 ;止呕合剂降低了呕吐发生率 ,减少 5 -HT的含量 ,提高NO的水平。中药组血、胃肠组织中 5 -HT、5 -HIAA浓度都较NS组明显下降而NO水平却明显高于NS组。认为 ,DDP致呕与胃肠组分泌 5H增多、NO减少有关。结论 :DDP诱发呕吐的机制与其提高5 -HT水平 ,降低NO水平有关 ,止呕合剂的胃肠道机制与其降低 5 -HT水平 ,提高NO水平有关。
Objective:to study the gastrointestinal mechanism of DDP-inducing emesis and the action of Zi-Ou-He-Ji to DDP-inducing emesis.Methods:the emesis rate of 30 cats were recorded and the levels of NO and 5-HT in the blood and gastrointestinal tissues were measured by biochemical analysis.Results:DDP caused the emesis rate increased and Zi-Ou-He-Ji could decrease it.DDP improved the blood level of 5-HT,reduced the blood level of NO,while the actions of Zi-Ou-He-Ji were opposite to the above.Conclusions:the gastrointestinal mechanism of DDP-inducing emesis was that DDP increased 5-HT level and decreased NO level.The action of Zi-Ou-He-Ji was increased the NO level and decreased 5-HT level.
出处
《中医药学刊》
CAS
2002年第3期311-313,共3页
Study Journal of Traditional Chinese Medicine
基金
辽宁省科技厅自然基金项目 (No 972 132 )
