摘要
目的 :观察中药双甲五灵胶囊治疗肝纤维化的疗效。方法 :将 96例患者随机分为双甲五灵胶囊治疗组(A组 )和基础保肝对症治疗对照组 (B组 ) ,观察两组治疗前后临床症状、体征、肝功能 [总胆红素 (TBi L)、丙氨酸转氨酶 (AL T)、白蛋白 (AL B) ]、血清透明质酸 (HA)、 型前胶原 (PC )、转化生长因子 β1 (TGF- β1 ) ,并进行统计学处理。结果 :双甲五灵胶囊对改善乏力、纳差、腹胀、肝区不适等症状及脾大回缩、恢复肝功能疗效明显 ,并能降低血清 HA、PC 、TGF- β1 浓度 (P <0 .0 5 )。结论 :双甲五灵胶囊治疗肝纤维化效果较好 ,未发现副作用。
Objective:To observe the effect of Shuangjia wuling Capsule on hepatic fibrosis.Methods: Ninety six patients with chronic hepatitis B and hepatic cirrhosis were randomly divided into two groups:Shuangjia wuling capsule group(group A) and control group(group B).Before and after the treatment, clinical symptoms and signs, liver function, serum hyaluronic acid(HA), procollagen Ⅲpeptide (PCⅢ) and transforming growth factor beta1(TGF β 1)were examined and dealed with statistics. Results:Group A has better therapeutic effect on improving clinical symptoms and decreasing the contents of HA,PCⅢand TGF β 1 than group B(P<0.05).Conclusion: Shuangjia wuling capsule has good therapeutic effect on hepatic fibrosis without side effect.
出处
《中国中西医结合消化杂志》
CAS
2002年第3期159-161,共3页
Chinese Journal of Integrated Traditional and Western Medicine on Digestion
关键词
临床研究
肝炎
肝纤维化
双甲五灵胶囊
治疗
Shuangjia uling capsule
chronic hepatitis
hepatic fibrosis
hyaluronic acid
procollagen Ⅲ peptide
transforming growth factor beta
