流行性出血热血小板膜糖蛋白自身抗体研究的初步报告

PRELHVIINARY REPORT ON DETERMINATION OF AUTOANTIBODIES AGAINST PLATELET GLYCOPROTEIN IN PATIENTS WITH EPIDEMIC HEMORRHAGIC FEVER

测定了37例流行性出血热(EHF)患者血浆抗血小板膜糖蛋白自身抗体。发现29.73％的患者血浆中抗膜糖蛋白自身抗体阳性,其中,抗膜糖蛋白Ib阳性率为13.51%(5/37),抗膜糖蛋白Ⅱb抗膜糖蛋白Ⅱa阳性率分别为8.1％(3/37)和16.21％(6/37)。提示抗血小板膜糖蛋白自身抗体可能参与了EHF发病。本实验为EHF患者免疫发病机制的深入研究提供了依据。

Plasma autoantibodies against platelet glycoprotein ( Anti-GP antibody ) were detected in 37 patients with epidemic hemorrhagic fever ( EHF ) by enzyme-linked immuno-sorbent assay ( ELISA ) .The overall positive rate for anti-GP antibodies was 29.73%. Among tbe anti-GP antibodies, anti-GP Ib was positive in 13.51%, anti-GP Ⅱb8.1% and anti-GP Ⅲa 16.21%. Apparently the changes were not related to blood platelet count ( BPC ) and the severity of hemorrhage. The authors believe that anti-GP antibodies may play a role in the pathogenesis of EHF.