利培酮与氯丙嗪治疗酒精所致精神障碍对照研究

A comparison study of risperidone and chlorpromazine in the treatment of mental disorders due to use of alcohol

目的 探讨利培酮对酒精所致精神障碍的临床疗效。方法 将符合入组标准的70例患者随机分为两组,分别服用利培酮或氯丙嗪治疗6周。用阳性与阴性症状量表(PANSS)和副反应量表(TESS)评定疗效和不良反应。结果 利培酮组有效率为71.4％,氯丙嗪组有效率为42.9％,二组差异有显著性。结论 利培酮对酒精所致精神障碍的疗效优于氯丙嗪,且不良反应较少。

Objective The study was to investigate the clinic effects of risperidone in the treatment of mental disorders due to use of alcohol. Methods A total 70 patients who met the diagnostic criteria of CCMD - 2 - R were randomly assigned to treatment with risperidone and chlorpromazine for 6 weeks. PANSS and TESS were used to assess the clinic and side effects. Results The therapeutic effect rate of risperidone was 71.4%, and the therapeutic effect rate of chlorpromazine was 42.9% . There was significant difference between the two groups. Conclusion Risperidone has better clinic effects than chlorpromazine in the treatment of mental disorders due to use of alcohol and less side effects.