氟西汀与丙咪嗪治疗抑郁症的临床对照研究

A comparative study of fluoxetine and imipramine in the treatment of depression

目的 研究氟西汀与丙咪嗪治疗抑郁症的临床疗效和副反应。方法 对42例符合CCMD-2-R诊断标准的重性抑郁症住院患者,随机分组,分别用氟西汀和丙咪嗪治疗6周,用汉密尔顿抑郁量表(HAMD)和临床疗效总评量表(CGI)评定临床疗效,用副反应量表(TESS)评定副反应。结果 氟西汀组显效率85.7％,丙咪嗪组显效率为76.2％,两者无明显差异(P>0.05)。氟西汀组副作用较丙咪嗪组少而轻。结论 氟西汀治疗抑郁症疗效好,副反应少而轻。

Objective To determine the efficacy and side effects of fluoxetine in the treatment of patients with depression . Methods 42 patients who met the CCMD - 2 - R criteria of major depression were randomly divided into research (fluoxetine) and control (imipramine) groups for the treatment of 6 weeks.The efficacy were assessed by Hamilton Depression Rating Scale (HAMD) and Clinical Global Impression( CGI) ,and the side effects were assessed by Treatment E-mergent Symptoms Scale (TESS) .Results There was no significant difference in the efficacy (P > 0.05) .The response rate was 85.7% and 76.2% for fluoxetine and imipramine respectively, while fluoxetine had less side effects. Conclusion Fluoxetine is an effective antidepressant with less side effects compared with imipramine.