依诺肝素治疗老年不稳定型心绞痛30例近期疗效观察

Short-term efficacy observation of Enoxaparin in 30 elderly patients with unstable angina

目的 观察依诺肝素治疗老年不稳定型心绞痛的近期疗效。 方法 将 5 5例老年不稳定心绞痛患者随机分为 2组 ,分别观察依诺肝素组治疗前后心绞痛发作频率、心电图及动态心电图变化和急性心肌梗死、急性血管再通术、院内死亡发生率 ;并与普通肝素组相对照。 结果 依诺肝素组患者心绞痛发作频率明显减少 ,心电图缺血明显改善 ;与对照组比较存在明显差异 (P <0 0 5 ) ;急性心肌梗死、急性血管再通术、院内死亡主要事件总发生率为 6 6 6 %,对照组为 16 %,2组比较差异显著。 2组均无严重出血。 结论 依诺肝素治疗老年不稳定型心绞痛疗效确切、安全。

Objective To investigate the therapeutic efficacy of enoxaparin in patients with unstable angina. Methods Fifty-five elderly patients with unstable angina were randomized into two groups-enoxaparin group and control(heparin therapy)group.We observed the frequency of angina onset,ischemic changes in ECG and Holter,the incidences of cardiac events(acute myocardial infarction,emergent revascularization),and in-hospital mortality respectively before and after enoxaparin therapy,and the outcomes were compared with those of control group. Results The frequency of angina onset was decreased and myocardial ischemia was improved in enoxaparin group.There was a statistically significant difference(P<0.05)comparing with control group.The incidences of total major events(acute myocardial infarction,emergent revascularization,and in-hospital mortality)were 6.66% and 16% in enoxaparin group and control group respectively.There was no severe hemorrhagic complication in two groups. Conclusion The efficacy and safety of enoxaparin therapy in elderly patients with unstable angina was proved.