慢性卡压周围神经损伤后感觉神经元内转化生长因子β_1的表达

Expression of transforming growth factor beta1 in the sensory neurons following the chronically compressed peripheral nerve injury

目的 观察大鼠坐骨神经慢性卡压伤后背根神经节内TGF β1表达的变化 ,了解TGF β1在周围神经损伤修复过程中的作用。方法 3 0只雄性SD大鼠 ,造成右侧坐骨神经慢性卡压伤。分别于正常时及术后 1、2、4、6、8周取L5背根神经节 ,行组织学和免疫组织化学观察。结果 术后TGF β1表达逐渐升高 ,4周时达到高峰 ,以后TGF β1表达的量有所减少。结论 TGF β1参与周围神经挤压伤后的病理生理改变 。

Objective To observe the expression changes of transforming growth factor beta1(TGF β 1) in dorsal root ganglion(DRG)after the chronically compressed sciatic nerve injury,and find out the function of TGF β 1 in the repair of peripheral nerve injury. Methods Thirty male Sprague Dawley rats were used. The model of chronic compression of the right sciatic nerves was set up. The histological and immnohistochemical examinations of L5 DRG were performed at normal condition, and at postoperative weeks 1,2,4,6,8 ,respectively. Results The expression of TGF β 1 slowly increased in both groups, and peaked at week 4. From then on, it decreased gradually. Conclusions The TGF β 1 not only participates in the pathophysiological process of peripheral nerve injury, but plays a certain role in its repair as well.