奶山羊单剂量肌肉和静脉注射丁胺卡那霉素后乳药浓度测定

DETERMINATION OF DRUG CONCENTRATION IN MILK AFTER INTRAMUSCULAR AND INTRAVENOUS INJECTION OF AMIKACIN IN MILKING GOAT

本文报道了常规单剂量肌注和静注国产丁胺卡那霉素后乳药浓度变化,探讨了全身给药对乳房局部感染的治疗效果。对16只泌乳萨能奶山羊常规单剂量(D=7mg/kg)肌注丁胺卡那霉素的研究表明:给药后12小时有9只测到乳药浓度(0.18～0.65μg/ml),24小时仅一只测到乳药浓度,36小时所有羊乳药残留皆低于检测限(0.1μg/ml;对其中10只羊同剂量静注给药后12小时,仅一只未测到乳药浓度,24小时仅一只测到乳药浓度,36小时乳药残留皆低于检测限。 以上乳药浓度测定表明:常规剂量以每日一次或两次全身给药对敏感菌所致乳房炎治疗效果不确实(乳药浓度达不到最低抑菌浓度);根据乳药残留量提出休药期为24小时。

A Bacillus substile (63501) disc assay technique was used for determination of Amikacin concentration in milk with a 0.lμg/ml sensitivity limit.By this method, the drug concentration was determinable in the milk of only one goat ( milked twice daily ) for 24 hrs after a single IM and IV dose of 7 mg/kg. It is concluded that the milk from third milking ( i.e.36 hrs later ) is free from the drug and safe to eat. Because the concentration of some milk samples for 12 hrs after a single IM and IV dose of 7 mg/kg is below the MIC of the bacteria which cause Mastitis, the treatment effect of mastitis after the IM and IV injection of 7mg/kg is not sure. The mastinjection should be recommended.