2型糖尿病的胰岛素及C-肽释放水平

Release level of insulin and C-peptide in type 2 diabetes

目的探讨2-型糖尿病(DM)的胰岛素(INS)释放及C-肽(C-P)释放水平曲线,为DM病人的诊治提供实验依据。方法与口服葡萄糖耐量试验(OGTT)同步,抽取DM病人空腹(0h)及餐后(口服含100g面粉馒头)1h、2h、3h的静脉血,用放射免疫分析(RIA)方法测定血清中INS及C-P含量,同时与正常人组作对照。结果本文共检测2-型DM病人236例,与正常人组比较,0h、1h、2h、3h四次的INS及C-P水平差异均有非常显著意义(P<0.01),只不过DN组0h、3h结果较正常人显著为高,而1h、2h却显著为低(C-P2h高于正常)。结论2型DM病人INS及C-P释放曲线上升迟缓,其高峰在餐后2h或3h,揭示患者存在INS抵抗(IR)或INS分泌不足。

Objective:We have studied the release level cur ve of insulin and C-peptide in type 2d iabetes.To provide test basis that making a diagnosis and giv ing treatment for diabetic patients.Methods:To take oral glucose tolerance test meanwhile drew blood from diabetic patients' vein in empty stomach(0h)and 1h,2h,3h after meal,by using rad io immunoanalysis.Then assayed insulin and C-peptide conte nt of the serum and compared diabetic patients with healthy subjects.Results:To compare236diabetic patients with healthy s ubjects.The level differ great sign ificance in insulin and C-peptide of0h,1h,2h,3h(P<0.01).The insulin and C-peptide of 0h,3h w ere higher in diabetic patients than those in the healthy subjects but 1h,2h were lower(C-p 2h were higher).Conclusion:The release curve of insulin and C-peptide in type 2diabetes went up slowl y.The high-est in 2h or 3h after meal.The study in dicated that insulin resistance or i nsulin of diabetie patients' secrete insufficiently.