PTCA前后血清IL-6、TNF-α水平的变化

Changes of Serum IL-6 and TNF-αBerote and After PTCA

目的 探讨 PTCA引起早期炎性反应的机制。方法 观察 33例 PTCA术前及术后 4 h血清 IL - 6、TNF-α水平。对成形术中球囊阻断冠脉引起的缺血的强度进行量化。结果 PTCA后 4 h IL - 6、TNF-α水平显著高于术前 (P<0 .0 1)。等级相关分析显示 ,PTCA后 IL - 6、TNF-α水平升高幅度之间 ,以及升高幅度与缺血强度之间相关性良好 (P均 <0 .0 2 )。结论 IL - 6、TNF-α是反映 PTCA术后早期炎性反应的敏感指标。心肌缺血 /再灌注是诱发 PTCA后早期炎性反应的重要机制。应尽可能减少

Objective To investigate the mechanism underlying the early inflammatory response after PTCA.Methods The sera levels of IL 6?TNF α were measured before and 4 h after PTCA by sandwich double epitope ELISA in 33 cases.The extent of myocardial ischemia induced by balloon inflation were quantified by a scoring sytem.Results 4 h after PTCA,IL 6?TNF α levels increased significantly(P<0.01).The results of rank correlation showed the elevations of IL 6?TNF α after PTCA correlated well.Both the elevations of IL 6 and TNF α correlated well with the extent of ischemia(P<0.02).Conclusion IL 6?TNF α were sensitive markers of the early inflammatory response after PTCA;Myocardial ischemia reperfusion injury could be an important mechanism underlying the early inflammatory response after PTCA.It should be necessary to reduce the ischemia stimulation during PTCA.