CD56在急性白血病细胞中的表达及临床意义

Expression of CD56 in Acute Leukemia and Its Clinical Significance

为了探讨CD5 6在急性白血病细胞中的表达情况及意义 ,采用多色流式细胞术 (FCM )对 70例急性白血病患者细胞表面CD5 6及其它白细胞分化抗原表达进行了分析。结果表明 ,70例中有 16例 ( 2 2 .86 % )表达CD5 6 ,急性髓性白血病 (AML)的CD5 6阳性表达率 ( 15 / 31,4 8.39% )明显高于急性淋巴细胞白血病 (ALL) ( 1/ 35 ,2 .86 % )(P <0 .0 1)。CD5 6在AML各亚型中表达也有差异 ,AML M0 , M1和 M2 中阳性率 ( 11/ 15 )明显高于AML M3 , M4和 M5( 4 / 16 ) (P =0 .0 13)。 15例CD5 6 +的AML病例中表达HLA DR 13例 ( 4 1.94 % ) ,两者呈明显正相关(r =0 .4 39,n =31,P =0 .0 14 )。结论 :CD5 6主要在AML中表达 ,对AML的诊断。

In order to investigate the expression of CD56 on acute leukemia cells and its clinical significance, samples from 70 patients with acute leukemia were analyzed with multicolor flow cytometry to determine the CD56 and other leukocyte differentiation antigens. The results showed that 16 of 70 cases (22.86%) were identified to express CD56, of which 1/35 (2.86%) patients with acute lymphocytic leukemia (ALL) and 15/31 (48.39%) with acute myelocytic leukemia (AML) were CD56 positive. The positive rate of CD56 in AML was significantly higher than that in ALL (P<0.01) . The expression of CD56 varied in AML subtypes. The positive rate (11/15) of CD56 in AML M 0, M 1 and M 2 was significantly higher than that in AML M 3, M 4 and M 5 (4/16) (P=0.013). 13 of 15 AML with CD56 expression were also positive for HLA DR (41.94%), and a significant positive correlation was found between the expression of CD56 and HLA DR (r=0.439, P=0.014). It was concluded that CD56 mainly expressed in AML cells. The analysis of CD56 expression on acute leukemia is of great value in the diagnosis, prognosis prediction and monitoring of minimal residual disease in AML patients.