成体干细胞多能性研究进展

The progress of studies on multipotential of adult stem cell

成体干细胞是存在于机体组织的一类原始状态细胞。它们能够进行自我复制和特异分化。用于维持新陈代谢和创伤修复。近年来越来越多的实验表明成体干细胞具有多向分化潜能,一种组织的干细胞可以分化成其他组织类型的细胞。作者介绍了国际上对成体干细胞概念的新看法,讨论了成体干细胞多能性的调控机理及与之相关的研究方法,还简要概括了成体干细胞在理论和临床应用上的重要意义。

Adult stem cells are primary cells exist in tissues of organism which can selfrenew and differentiate specifically, and can keep metabolism and repair damage. However, a series of experiments has shown recently that stem cells from certain adult tissues can generate additional cell types, that is adult stem cell has multipotential. This new character of adult stem cell has brought new idea to the treatment of many diseases and thus become the highlight in the field of biomedicine. In this review, we introduced the new concept about adult stem cell, discussed how adult stem cell multipotential may be regulated and related research methods, briefly summarized the important significance of adult stem cell in theory and clinical application.