飞行(学)员ACE基因的多态性

The Polymorphism of the Angiotensin-converting-enzyme in the Pilots and Student-pilots

血管紧张素转化酶 (ACE)第 16内含子的插入 缺失多态性与运动员耐力水平有关 .为了解这一多态性与飞行员飞行耐力的关系 ,对不同阶段飞行人员ACE第 16内含子基因型进行了分析和比较 .结果显示 ,ACEDD基因型百分率在招飞体检应征人员为 12 5 %、基础飞行学院学员 (未飞 )为 11 5 %、飞行学院初教机飞行学员为 10 0 %、歼击机飞行员为 3 0 % .歼击机飞行员组D等位基因频率及DD基因型明显低于其他 3组 (P <0 0 1) ,而后 3组之间无明显差异 (P >0 0 5 ) .进而观察到 ,飞行员体能测试成绩优者 ,无DD基因型 .提示 ,飞行员体能表现与ACE第 16内含子的插入 缺失多态性有关 ,具有I等位基因者 ,体能较好 ,飞行耐力也较好 .

The association of insertion/deletion (I/D) polymorphism in the 16th intron in angiotensin\|converting\|enzyme (ACE) with sportsmen physical ability was reported.The genotype of the 16th intron in ACE of normal control, candidates in aviation school, student\|pilots and jet pilots were analyzed and the DD genotype decreased to 12\^5%,11\^5%,10% and 3%, respectively. There were significant differences in DD genotype and allele frequency between the jet pilot group and the other three groups, and no difference among the other three groups. In the pilots subjected to physical performance evaluation,no one who got excellent score had DD genotype. Physical performance of pilot is associated with the I/D polymorphism of the 16th intron in ACE gene. The pilots with I allele showed good physical performance.