犬肝动脉介入性热疗的安全性

Safety of Interventional Thermotherapy through Hepatic Artery in the Dog

经犬肝动脉灌注入 60℃生理盐水 1 80ml,持续 3 0min。观察、比较热灌注前后肝脏穿刺活检及肝、肾功能的动态变化情况。结果是 ,①谷丙转氨酶 (ALT)、谷草转氨酶 (AST)于灌注后 2 4h开始升高 ,72h达到高峰 (P <0 0 1 ) ,1 68h后逐渐下降 ,2 1 6h后恢复正常 ,总胆红素 (T BIL)、白蛋白 (ALB)、γ GT无明显变化 (P >0 0 5 ) ;②肝组织可见一过性淋巴细胞浸润、肝细胞混浊肿胀 ,1 68h后恢复正常 ;③肾功能尿素氮 (BUN)、肌苷 (Cr)无显著性变化 (P >0 0 5 ) ,尿酸 (UA)呈一过性增高 (P <0 0 5 )。结果说明 ,经肝动脉60℃灌注液介入性热疗对犬肝组织有一过性损伤 ,对肝。

To investigate the influence of interventional thermotherapy at 60℃ through hepatic arery on dog′s liver and kidney function,180 ml saline at 60℃ was perfused through hepatic artery in 30 minutes. Changes of the dog′s liver and kidney function were observed. Results:ALT and AST increased 24 hours after perfusion and reached the peak ( P <0 01)72 hours later,but recovered in 9 days,while BIL,ALB and γ\|GT showed no significant changes( P >0 05). Damage to liver tissue is temporary. BUN and Cr showed no significant changes,too. UA increased temporarily. Conclusion:Interventional thermotherapy has transient influence on dog′s liver and kidney function.