2级高血压病中医证型与血浆ET、AngⅡ、TXA_2关系及川芎嗪的影响

Study on Plasma Endothelin, Angiotensin II, Thromboxame A_2 in Different TCM Type of Grade 2 Hypertension and Effect of Tetrametuyl Pyrazine

目的:探讨2级高血压病(EH2)中医证型与血浆ET、AngⅡ、TXA2水平的关系,进而观察川芎嗪对其的影响。方法:测定83例不同中医证型EH2患者血浆ET、AngⅡ、TXB2的含量,同时采用川芎嗪治疗,观察EH2及血瘀组治疗前后血浆ET、AngⅡ、TXA2的变化情况。结果:肝火亢盛、血瘀组ET水平显著升高,实证组、血瘀组AngⅡ、TXB2水平显著升高,川芎嗪能显著降低EH2及血瘀组异常的ET、AngⅡ、TXB2水平。结论:血浆ET、AngⅡ、 TXA2可以作为EH2判断病情轻重及辨证论治的有效指标。

Objective:To investigate the changes of endothelin (ET), angiotensin II (Ang II), Thromboxame A2 (TXA2) in different TCM Type of grade 2 essential hypertension (EH2) and effect of Tetrametuyl Pyrazine. Methods:Plasma ET, AngII, TXA2, before treated and after treated, were measured in 83 patients with EH2 and normal subjects. Results:The level of ET in the groups of overabundant liver-fire and blood stasis syndrome was significantly increased. The level of AngII, TXB2 in the excess syndrome and blood stasis syndrome were significantly increased. The excessive level of ET, AngII, TXB2 were significantly lower in the treated group with EH2 and the group of blood stasis syndrome. Conclusion:The level of ET, Ang II, TXA2 in patients with EH2 were associated with Syndrome-Type and treatment in TCM and state of illness.