临床主要病原菌耐药谱变化分析

Antibiotic Resistance Spectrum of Main Clinical Pathogens: An Analysis

目的 了解 2 0世纪 90年代临床主要病原菌耐药谱的变化。方法 应用回顾性调查分析方法对我院 1990～ 1999年临床标本中分离的金黄色葡萄球菌、大肠埃希菌、肺炎克雷伯菌的药敏试验进行统计分析。结果 金黄色葡萄球菌对卡那霉素、氨苄西林、庆大霉素、SMZco、头孢唑林、头孢哌酮、多西环素 ,大肠埃希菌对多粘菌素、四环素、氯霉素、卡那霉素、阿米卡星、氨苄西林、庆大霉素、SMZco、头孢唑林 ,肺炎克雷伯菌对阿米卡星的耐药率已发生显著性变化 (P<0 .0 5 )。结论 以上 3种病原菌的耐药谱进入 2 0世纪 90年代以来 ,已发生显著性变化。

OBJECTIVE To study the change in antibiotic resistance spectrum of some main clinical pathogens during 1990s. METHODS To study retrospectively the antibiotic resistance of Staphylococcus aureus, Escherichia coli and Klebsiella pneumoniae isolatca from clinical samples in our hospital in 1990s. RESULTS The resistance rates of kanamycin, ampicillin, gentamicin, SMZco, cefazolin, cefoperazone, doxycycline to S.aureus, polymyxin B, tetracycline, chloramphenicol, kanamycin, amikacin, ampicillin, gentamicin, SMZco, cefzolin to E.coli and amikacin to K.pneumoniae have changed obviously (P<0.05). CONCLUSIONS The antibiotic resistant spectrum of three pathogens above mentioned has changed significantly.