血浆血管内皮生长因子及血管紧张素Ⅱ与糖尿病肾病的关系

Relationship between the changes of angiotensin Ⅱ and vascular endothelial growth factor in plasma and the occurrence of diabetic nephropathy

目的 :检测糖尿病患者血浆血管紧张素Ⅱ (ATⅡ )和血管内皮生长因子 (VEGF)浓度变化 ,并探讨二者之间关系及其在糖尿病肾病发生、发展过程中的作用。方法 :98例Ⅱ型糖尿病患者分为两组 ,4 3例为糖尿病肾病组(DN) ,5 5例为糖尿病非肾病组 (NDN)。分别测定各组患者血浆中血管紧张素Ⅱ、血管内皮生长因子、糖化血红蛋白(GHbAlc)及尿微白蛋白 (UmALB)的含量。结果 :DN组和NDN组患者ATⅡ、VEGF、GHbAlc及UmALB水平均明显高于正常对照组 (P <0 0 1) ;DN组ATⅡ、VEGF及UmALB明显高于NDN组 (P <0 0 1) ,但是GHbAlc水平在两组之间无显著差异 (P >0 0 5 ) ;各组糖尿病患者血浆ATⅡ和VEGF水平呈显著正相关 (r=0 4 6 5 ,P <0 0 5 ) ,血浆VEGF水平与尿微白蛋白呈高度正相关 (r =0 5 4 0 ,P <0 0 1)。结论 :糖尿病患者血浆ATⅡ和VEGF明显升高 ,二者之间存在相互作用关系 。

AIM: To measure the concentrations of angiotensinⅡ(ATⅡ) and vascular endothelial growth factor(VEGF) in plasma of diabetics and investigate the relationship between ATⅡ and VEGF and the role of VEGF in occurrence and development of diabetic nephropathy(DN). METHODS: 98 type Ⅱ diabetics were divided into two groups: 43 were in diabetic nephropathy group and 55 in non-diabetic nephropathy (NDN) group, and 25 healty persons were in control group. We measured the levels of ATⅡ, VEGF, glycosylated hemoglobinC (GHbAlc) in plasma and urinary microalbumin(UmALB), respectively. RESULTS: The levels of ATⅡ, VEGF, HbAlc and UmALB in DN group and NDN group were increased significantly compared with control group( P< 0 01); The concentrations of ATⅡ, VEGF and UmALB in DN group were obviously higher than that in NDN group( P< 0 01), but there was no significant difference of GHbAlc between DN and NDN; There was a positive correlation between ATⅡ and VEGF( r= 0 465, P< 0 05), and VEGF was positively correlated with UmALB( r= 0 540, P< 0 01). CONCLUSION: The levels of ATⅡand VEGF increased significantly in plasma of diabetics, and ATⅡ and VEGF may involve in the occurrence and development of diabetic nephropathy.