三七脂溶性化学成分的研究

Studies on lipophilic constituents of Panax notoginseng

目的 对三七的脂溶性部位进行化学成分研究。方法 以金黄色葡萄球菌的生长抑制实验为分离指导 ,采用硅胶柱层析、制备 TL C进行分离 ,通过波谱技术 (IR、MS、1 HNMR、1 3CNMR、DEPT、HMQC、HMBC)分析鉴定其化学结构。结果 从三七的石油醚提取物中分离得到 3个化合物 ,分别鉴定为 :人参炔醇 (panaxynol, )、人参环氧炔醇 (panaxydol, )和 β-谷甾醇 (β- sitosterol, )。结论 化合物 , 从三七中的分离得率分别为 0 .0 1%和0 .0 33%。

Object To study the chemical constituents in the lipophilic portion of Panax notoginseng (Burk.) F H Chen Methods Through monitoring each fraction based on antimicrobial experiment of Staphylococcus aureus Rosenbach, the constituents were isolated on silica gel column chromatography and preparative TLC, and the chemical structures were identified by means of spectral data (IR, MS, 1HNMR, 13 CNMR, DEPT, HMQC, HMBC) Results Three compounds were isolated from its petroleum ether extract and identified as: panaxynol (Ⅰ), panaxydol (Ⅱ), and β sitosterol (Ⅲ) Conclusion Compounds Ⅰ, Ⅱ having strong antimicrobial activity against S aureus were obtained from this plant with the yields of 0.01% and 0.033%