颐心宁对束缚应激大鼠心电图、血清皮质醇的影响

Effect of YIXINNING on ECG and serum hydrocortisone in restrained stress rats

目的 评价颐心宁抗应激性心肌损伤的效果。方法 动态观察颐心宁对束缚应激大鼠心电图、血清皮质醇的干预作用。结果 束缚应激 1,2 ,4周时 ,应激模型组大鼠心率增加、ST段明显移位、T波高耸直立 ,血清皮质醇水平增高 ;颐心宁干预组、颐心宁倍量组较单纯应激大鼠心率减慢、ST段移位减轻、T波直立幅度下降且多呈双相 ,血清皮质醇水平降低 ;而颐心宁 1/ 2量组、蒸馏水干预组与单纯应激大鼠比较则无统计学意义。结论 颐心宁具有抗应激性心肌损伤、改善心脏功能的作用 ,颐心宁对血清皮质醇的调节可能是其抗应激性损伤的作用机制之一。

Object To evaluate the effect of YIXINNING on anti cardiomuscular injury caused by stress. Methods To dynamically observe the interference of YIXINNING on electrocardiogram (ECG) and serum hydrocortisone of restrained stress rats. Results When 1, 2, 4 week of restrained stress, the heart rate was increased, the ST of ECG was visibly displaced, T wave of ECG was upright lofty and serum hydrocortisone level was risen in stress model group compared with the control group. In YIXINNING interference group and double dose group, it slowed heart rate, displaced ST of ECG, depressed upright T wave of ECG with double phases and decreased serum hydrocortisone level compared with the stress model group, while in half dose group, distilled water interference group, it showed no statistical significance. Conclusion YIXINNING has the functions of antistress myocardium injury and improving heart function. The regulation of YIXINNING on serum hydrocortisone may be one of the mechanisms of its antistress injury.