糖尿病患者红细胞2,3-DPG的变化

ERYTHROCYTE 2,3-DIPHOSPHOGLYCERATE CHANGE OF PATIENTS WITH DIABETES MELLITUS

对42例无酮在糖尿病患者红细胞2,3-二磷酸甘油酸(2,3-DPG)变化进行多元分析发现,持续高血糖、高甘油三酯血症和静脉氧分压(PVO_2)增高是2,3—DPG的主要影响因素。低血磷和缺磷亦可影响2,3—DPG生成。因此,控制血糖及血脂、积极防治神经损害和适当补磷,有利于2,3-DPG恢复而改善糖尿病患者组织缺氧。

With polyfactor stepwise regression analysis,influential elements of erythrocyte 2,3-diphosphoglycerate (2,3-DPG) change were investigated in 42 non-ketotic diabetics. Glycosylated hemoglobin (HbA1), triglyceridemia and venous oxygen tension (PvO2) were the principal factors of 2,3-DPG change in erythrocyte.So were hypophosphatemia and phosphate depletion.It is suggested that diabetic control,prevention of neuropathy,which may induce arteriovenous shunting and increase PvO2,and appropriate phosphate supplementation,may be conducive to restoration of erythrocyte 2,3-DPG concentration and improvement of diabetic anoxia .