二甲亚砜治疗实验性脑水肿

DIMETHYL SULPHOXIDE TREATMENT IN EXPERIMENTAL BRAIN EDEMA

21只家兔急性脑水肿模型分为三组,脑水肿建立后3h分别静脉注入10％二甲亚砜、20％甘露醇和5％葡萄糖(空白对照);观察颅内压,脑组织含水量、血压和血尿等变化。结果表明DMSO比甘露醇降低颅内压作用快,下降幅度亦较大,但持续时间较短。用10％DMSOlg/kg的浓度和剂量快速静脉推注,未发生血尿。电镜观察二药均有减轻脑水肿的形态学改变。因此DMSO可作为一种降低颅内压减轻脑水肿的药物。

Twenty one rabbits with experimental brain edema induced by intracarotid injection of pertussis vaccine were randomly divided into three groups: 10% Dimethyl sulfoxide (DMSO, 20% Mannital groups, and 5%Glucose as control.3h after giving the vaccine, experimental animals received different drug therapy, all administrated intravenously. The intracranial pressure (ICP), mean arterial pressure (MAP), and brain tissue water were montored. ICP and brain edema reduced sinificantly in both DMSO and mannital groups. The ICP decrease initiated quicker but the lasting time was shorter in DMSO group than that of mannital group.No obvious hematuria was found in DMSO group. It is suggust-ed that DMSO may be used in reducting ICP.