1,2,3,5-O-四乙酰-β-D-呋喃核糖的合成新工艺

New Process for Synthesis of 1,2,3,5-O-tetraacetyl-β-D-ribofuranose

通过对三氮唑核苷合成工艺中乙酰化反应机理的分析 ,研究了采用肌苷 80 g、醋酐 32 0g为原料 ,固体酸PMB -Ⅱ 0 5 g为催化剂的乙酰化新工艺 ,制得 1,2 ,3,5 O 四乙酰 β D 呋喃核糖 82 6 g ,最高产率为 87% ,熔点为 83

A new process for synthesis of ribavirin was firstly carried out with 80 g carnine and 300 g acetic anhydride with 0 5 g solid acid (PMB-Ⅱ) as catalyst.The mechanism of acetylation reaction in this new process was discussed.The result was satisfactory.The highest yield of 1,2,3,5 O tetraacetyl β D ribofuranose was 87%(82 6 g,with melting point of 83 5 ℃).