环磷酰胺冲击治疗难治性肾病综合征临床观察

Clinical observation of treatment of refractory nephrotic syndrome by cyclophosphamide stosstherapy

目的 探讨环磷酰胺 (CTX)冲击治疗难治性肾病综合征 (RNS)的临床疗效。方法 CTX 9～1 2mg/kg加入生理盐水内静滴 ,每周 1次 ,总量≤ 1 50mg/kg。并与采用CTX冲击治疗前的单纯应用强的松和 (或 )雷公藤多甙片治疗作前后自身对照。结果 CTX冲击治疗后完全缓解 2 0例 ,部分缓解 6例 ,总有效率 1 0 0 %。随访 8～ 42个月 ,平均 2 0个月 ,复发 3例。结论 大剂量CTX冲击治疗RNS ,有可靠疗效 。

Objective To study the clinical effects and side effects of cyclophosphamide(CTX) stosstherapy to treat refractory nephrotic syndrome(RNS).Methods CTX 9～12mg/kg added into normal saline was administrated intravenously,once a week.The total dose was less than 150mg/kg.Before the stosstherapy,the patients got the simple treatment of prednisone or tablet Lei Gong Ten Duo Dai as control.Results After the stosstherapy,20 cases got complete remission and 6 cases got partial remission.The total effective rate was 100%.The follow up time was 8～42 months.The average time was 20 months.There were 3 cases of recurrence.Conclusion CTX stosstherapy had confirmed clinical effect in treatment of RNS.There are side effects.The therapy is worthy of popularization.