腺苷蛋氨酸治疗药物性肝损害疗效与血液中GSH变化关系

Treatment of ademetionine in drug derived liver lesion and glutathione change

目的 探讨应用腺苷蛋氨酸治疗药物性肝损害的疗效以及还原型谷胱甘肽 (GSH)对判断疗效的意义。方法 应用腺苷蛋氨酸对 1 4例因各种药物引起的肝损害给予治疗 ,连续静脉给药 80 0mg/d ,3周。动态观察治疗前后临床表现和各项肝功能指标及GSH水平变化情况。结果 治疗后精神、睡眠、食欲好转 ,乏力减轻 ,肝功能指标明显下降 ,GSH水平从治疗前的 6 2 1± 0 89mmol/L升至 7 40± 0 61mmol/L。结论 腺苷蛋氨酸对治疗药物性肝损害有明显疗效 ,能明显改善肝功能和抗氧化作用。

Objective To study the effects of ademetionine in drug derived liver lesion and its relation with glutathione level.Methods Fourteen patients were given ademetionine at a dose of 800mg per day intravenously for 10～17d.Results The subjective status of the patients improved after treatment.The level of ALT,AST,AKP and TBIL were decearsed to normal,and the level of GSH from 6.21±0.89mmol/L to 7.40±0.61mmol/L.Conclusion Ademetionine can accelerate recovery of drug derived liver lesion and GSH detection is beneficial to judging carative effect and prognosis.