摘要
肝阳上亢证患者血浆血栓素B_2、6-酮-前列腺素F_(1α)水平及其比值均升高。
Plasma TxB2, 6-keto-PGF1α were determined by radioimminoassay in 96 patients with Liver Yang Rising ( LYR) , 101 patients with Yin deficiency and Yang excess (YDYE, 18 patients with Liver-Kidney Yin deficiency (LKYD) and 70 healthy subjects used as control.The levels of TxB2, 6-keto-PGF1αand TxB2, / 6-keto-PGF1αratio of LYR group were 314. 3+15.4ng/L, 165.7+6.8ng/L and 2.02±0.10; respectively; of YDYE group 253.7±12.6, 157.0±5.4, 1.71±0.07; and of LKYD group 229.4±15.7, 145.8±9.7, 1.71±0.17 respectively. As compared with the data of the control group, 188.2±6.3ng/L, 142.8+6.0ng/L, 1.49+0.08, the TxB2, 6-keto-PGF1αand TxB2/6-keto -PGF1αratio of LYR group increased significantly. These data were consistent with the authors previous investigation that cAMP, cGMP levels increased and cAMP/ cGMP ratio decreased in LYR patients. It is suggested that disorder of TxA2and PGI2affect the metabolism of cyclic nucleotides, which might be an important pathophysiological feature in LYR.
出处
《湖南医科大学学报》
CSCD
1989年第1期43-45,共3页
Bulletin of Hunan Medical University
关键词
肝阳上亢证
血液
血栓素B2
Liver Yang Rising (CTM)
blood
thromboxanes
prostaglandins