蕲蛇酶治疗脑梗死临床观察

Clinical Observations on CerebralInfarction with Acutobin

目的 :观察蕲蛇酶注射液治疗急性脑梗死病人的疗效。方法 :对照组 41例病人 ,每天点滴丹参、神经细胞活化剂 ,口服阿斯匹林肠溶片 ,根据病情适量用甘露醇 ,血糖增高者加用胰岛素 ;治疗组 45例病人 ,在对照组用药的基础上加用蕲蛇酶 0 .75U +生理盐水 2 5 0ml静脉点滴 ,1～ 2h内滴完 ,一天一次 ,连用 10～ 15d。结果 :治疗组有效率 88.9%(4 0例 ) ,高于对照组的有效率 70 .7%(2 9例 ) ;治疗组总显效率 6 6 .7%(30例 ) ,显著高于对照组的总显效率 34 .1%(14例 ) ;治疗组中起病 2 4h内得到治疗的总显效率 ,显著高于起病 2 4h后才得到治疗的总显效率 (P<0 .0 1)。结论 :蕲蛇酶注射液为较安全、有效、价廉的生物降纤溶栓制剂 ,可推广应用于急性脑梗死病人的治疗 ,且疗效越早治疗越好。

Objective:To observe the effect of acutobin injection on Cerebral infarction.Methods:41 patients in the control group: intravenous drip salviae miltzorrhizae,neuronal activator,and aspirin are orally administrated daily:proper mannitol if necessary and proper insulin if the blood glucose level increases;45 patients in the treatment group, based on the control group,and acutobin 0.75u+0.9%NS 250 ml for intravenous drip within one to two hours,once daily for 10～15 days. Results: The effective rate of the treatment group was 88.9%(40 ones) and was higher than 70.7%(29 ones) in the control group, and the total obvious effective rate of the treatment group,which was 66.7%(30 ones), was much higher than that of the control group (34.1%, 14 ones).ln the treatment group,the obvious effective rate of patients treated in 24 hours was much higher than that of ones treated later than 24 hours since they became ill(P<0.01).Conclusion:The acutobin infection is a kind of safe, effective,low-end biocatalyst of defibrinnoge and a dissolution of thrombi. lt could be widely used on cerebral infarction: the earlier, the better.