乙型病毒性肝炎患者的血、尿β_2微球蛋白检测

SERUM AND URINE β_2MICROGLOBULIN IN PATIENTS WITH HEPATITIS B

用放射免疫法检测143例乙型病毒性肝炎患者血清与尿β_2微球蛋白。各型患者血与尿β_2微球蛋白均有明显增高,尤以重症肝炎显著,且其血清β_2微球蛋白变化与血浆肌酐值呈显著正相关。无症状HB_sAg携带者一般肝功能正常而β_2微球蛋白增加。对其临床意义进行了探讨。

Radioimmunoassay of serum and urine β2-microglobulin (β2-MG) in 143 cases of HBV infection were compared with those of 100 normal subjects. Both were elevated in patients with acute hepatitis, chronic active hepatitis, fulminant hepatitis and also in asymptomatic HBsAg carriers. Serum β2-MG were significantly higher in fulminant hepatitis than that in other three types. The increase of serum β2-MG was parallel to the severity of the disease. It might implicate prognostic significance. Apparent correlation between the plasma creatinine and serum β2-MG was noticed in patients with fulminant hepatitis (P< 0.01) . Urine β2-MG was also increased in various types of hepatitis. The abnormal values of serum and urine β2-MG in fulminant hepatitis may also be an early indication of kidney damage in cases with impending hepatorenal syndrome.