吉西他滨联合顺铂治疗老年非小细胞肺癌临床观察

CLINCAL OBSERVATION ON GAMZAR AND DDP REGIMEN IN THE MANAGEMENT OF NON-SMALL CELL LUNG CANCER

目的观察吉西他滨(健择,gemcitabine)联合顺铂(DDP)方案治疗晚期老年非小细胞肺癌的疗效和毒副反应。方法30例老年非小细胞肺癌采用GP方案。NP方案对照组30例。结果GP方案组有效率53.3%,NP方案组有效率40%,疾病进展时间(TTP)犤1犦GP组4月,NP组2月,毒性反应主要为骨髓抑制、恶心呕吐及静脉炎。结论健择加DDP的联合化疗是治疗老年非小细胞肺癌有效率高,毒性低,老年人可以耐受。

Objective To observe the therapeutic effects and toxicity of gemcitabine plus cisplatin(DDP) for the treatment of advanced non-small cell lung cancer(NSCLC), as compared with those of NVB plus DDP regimen. Methods 30 cases were treated with GP regimen,and 30 cases were treated with NP regimen as control. Results The response rate was 53.3% in patients with GP regimen, 40% in those treated with NP regime. TTP was four months in the GP and two months in the NP. The major toxic reactions in the two groups were tolerable, being myelo-suppression, nausea and vomiting,and local phlebitis. Conclusions GP regimen is effective for treating advanced non-small cell lung cancer.in elderly patients.