大剂量地塞米松冲击疗法联用肝素治疗“难治性”肾病综合征初步报告

COMBINATION OF LARGE DOSAGE DEXAMETHASONE WITH HEPARIN IN THE TREATMENT OF REFRACTORY NEPHROTIC SYNDROME

大剂量地塞米松联用肝素治疗“难治性”肾病综合征18例,单纯地塞米松冲击19例。前者尿蛋白明显减少,血清白蛋白明显上升,总有效率94.4％,显效率83.3％;近期疗效明显优于地塞米松组,可作为治疗“难治性”肾病综合征可取方法之一。

Eighteen cases of refractory nephrotic syndrome were treated with the combined therapy of large dosage dexamethasone (DXM) and heparin.Compared with large dosage DXM alone, the combined therapy was more significant in reducing proteinuria and improving serum albumin level (p<0.01).The data showed that in the group of combined therapy 94.4% of the cases were totally effective and 83.3% obviously effective while in the group of DXM alone, 42.1% of the cases were totally effective and 10.5% were obviously effective.It is considered that the therapeutic result of the combined therapy is better then large dosage DXM alone, and the combined therapy is an effective method to treat refractory cases of nephrotic syndrome.