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睫状神经营养因子对大鼠创伤性脊髓水肿的影响 被引量：1

Effects of ciliary neurotrophic factor on spinal cord edema in rats
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摘要 目的 :观察睫状神经营养因子 (CNTF)对大鼠创伤性脊髓水肿的影响及其可能的作用机制。　方法 :采用改良Allen打击法致SD大鼠T8脊髓损伤 ,分别于术前及术后 3天用干湿法测定脊髓组织水含量、用原子吸收分光光度计测定脊髓组织中Ca2 + 的含量。　结果 :脊髓损伤后局部组织含水量、Ca2 + 含量均显著增加 (P <0 .0 1) ,用CNTF治疗后水含量、Ca2 + 含量有明显下降 (P <0 .0 1) ,但和正常组相比仍有明显差异。　结论 :CNTF可能是通过阻止Ca2 + 内流、稳定细胞内外Ca2 + 平衡而起到减轻创伤性脊髓水肿的作用。 Objectives:To evaluate the effect and mechanism of ciliary neurotrophic factor (CNTF) on spinal cord edema in rats. Methods:SD rats were subjected to incomplete spinal cord injury (SCI) with modified Allen method. Contents of spinal cord tissue water and Ca 2+ were measured preoperatively and 3 days after SCI. Results:There were significant increases in the contents of spinal cord tissue water and Ca 2+ after injury, which were decreased obviously after treated with CNTF ( P < 0.01). Conclusions:CNTF may relieve spinal cord edema by regulating the balance of extracellular and intracellular calcium.
作者 许斌 贾连顺 李家顺 何成 吴宏
机构地区 南京军区南京总医院军区骨科中心 第二军医大学附属长征医院骨科 第二军医大学神经生物学教研室 福建省立医院骨科
出处 《医学研究生学报》 CAS 2002年第3期210-212,共3页 Journal of Medical Postgraduates
基金 国家自然科学基金资助项目 (批准号 :395 0 0 44)
关键词 脊髓损伤 脊髓水肿 睫状神经营养因子 Spinal cord injury Spinal cord edema Ciliary neurotrophic factor
分类号 R651.2 [医药卫生—外科学]
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参考文献13

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二级参考文献15

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医学研究生学报
2002年 第3期

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