摘要
Objective:To investigate the clinical usefulness in terms of estimation for glomerular filtration rate(GFR), we determined the serum cystatin C levels in 72 healthy adults , 63 children, and 109 patients with various renal diseases, and compared the serum cystatin C concentrations with serum creatinine levels. In addition, the renal function was evaluated in 5 adults receiving renal transplantations using cystatin C.Methods:Serum cystatin C levels were measured by a particle-enhanced nephelometric immunoassay on Dade Behring nephelometer system. Serum and urine creatinine concentrations were determined by use of Jaff’s kinetic assay.Results: The cystatin C concentration at birth was typically double that found in adults, then fell to a constant level after 1 year, a value that was maintained to about 60 years. The studies of cystatin C in the elderly showed that the circulation cystatin C levels rose gradually above 60 years. There was a significant positive correlation between serum cystatin C and creatinine level (r=0.921, P <0.01) in the patients with various renal diseases. Serum cystatin C was inversely and logarithmically correlated with creatinine clearance as shown in the equation lg cystatin C =-0.6061gCCr+1.209(r=-0.887, P <0.01). Serum cystatin C levels rose prior to creatinine concentrations and started to increase over normal range when creatinine clearance remained within normal range. After renal transplantation,cystatin C concentration significantly decreased during the first week(-43% vs -21% for creatinine) in patients without delayed graft function. In some cases of acute renal impairment, the increase in serum cystatin C values was more prominent than that of creatinine.Conclusion:Serum cystatin C is probably more attractive for estimation of renal function than serum creatinine and creatinine clearance especially for detection of the mild reduction of glomerular filtrate rate in patients with various kidney diseases. Serum cystatin C can also be used as an alternative marker of allograft function in adult transplant patients.
Objective:To investigate the clinical usefulness in terms of estimation for glomerular filtration rate(GFR), we determined the serum cystatin C levels in 72 healthy adults , 63 children, and 109 patients with various renal diseases, and compared the serum cystatin C concentrations with serum creatinine levels. In addition, the renal function was evaluated in 5 adults receiving renal transplantations using cystatin C.Methods:Serum cystatin C levels were measured by a particle-enhanced nephelometric immunoassay on Dade Behring nephelometer system. Serum and urine creatinine concentrations were determined by use of Jaff's kinetic assay.Results: The cystatin C concentration at birth was typically double that found in adults, then fell to a constant level after 1 year, a value that was maintained to about 60 years. The studies of cystatin C in the elderly showed that the circulation cystatin C levels rose gradually above 60 years. There was a significant positive correlation between serum cystatin C and creatinine level (r=0.921, P <0.01) in the patients with various renal diseases. Serum cystatin C was inversely and logarithmically correlated with creatinine clearance as shown in the equation lg cystatin C =-0.6061gCCr+1.209(r=-0.887, P <0.01). Serum cystatin C levels rose prior to creatinine concentrations and started to increase over normal range when creatinine clearance remained within normal range. After renal transplantation,cystatin C concentration significantly decreased during the first week(-43% vs -21% for creatinine) in patients without delayed graft function. In some cases of acute renal impairment, the increase in serum cystatin C values was more prominent than that of creatinine.Conclusion:Serum cystatin C is probably more attractive for estimation of renal function than serum creatinine and creatinine clearance especially for detection of the mild reduction of glomerular filtrate rate in patients with various kidney diseases. Serum cystatin C can also be used as an alternative marker of allograft function in adult transplant patients.
出处
《中国现代医学杂志》
CAS
CSCD
2002年第11期20-24,共5页
China Journal of Modern Medicine
关键词
肾小球过滤功能
肌酸酐
血管小球
肾疾病
Cystatin C
Creatinine
Glomerular
Filtration Function
Impaired Renal Function
