兔急性局限性颅高压模型经颅多谱勒频谱参数与脑灌注压相关性的研究

CORRELATION BETWEEN TRANSCRANIAL DOPPLER AND CEREBRAL PERFUSION PRESSURE IN ACUTE LOCALIZED ICH RABBIT MODEL

目的 :应用新西兰兔急性局限性颅高压模型 ,研究经颅多谱勒频谱参数与脑灌注压的关系。方法 :2 0只新西兰兔随机分为二组 ,实验组 12只 ,间断硬膜外水囊注水 ,TCD持续监测 ,直至动物死亡为止 ;对照组 8只 ,水囊不注水 ,TCD持续监测同样时间。结果 :随着ICP的升高 ,CPP降低 ;经颅多谱勒参数与CPP有一定关系 ,相关性强弱依次为 :RI>PI >cf=ce >Vd >Vm >Vs。结论 :经颅多谱勒参数可以定量地反映颅高压时脑灌注压的改变。

Objective:To evaluate the correlation between the parameters of TCD and cerebral perfusion pressure of acute localized intracranial hypertension model of New Zealand white rabbits. Methods:We divided 20 New Zealand white rabbits radomly into two groups, the experimental group (n=12) and control group (n=8). TCD in different time and different intracranial pressure was monitored in experimental group constantly until the animal died. TCD in control group was monitored at the same time.Results:The increase of ICP in experimental group was accordance with the dcrease of CPP and the parameters of TCD correlated with CPP tightly. The order of these parameters was RI>PI>cf=ce>Vd>Vm>Vs according to their contribution. Conclusions:CPP of this ICP model can be calculated by analyzing these parameters of TCD.