妊娠高血压综合征阴离子间隙的改变及其意义

ANION GAP CHANGES AND ITS CLINICAL SIGNIFICANCE IN PREGNANCY-INDUCED HYPERTENSION SYNDROME

目的 :探讨国人妊娠高血压综合征与阴离子间隙、血电解质、白蛋白水平的关系及其临床意义。方法 :采取回顾性研究方法分析 12 8例妊娠高血压综合征孕妇的临床资料及实验室检查 ,并按尿蛋白量分为三组 ,与正常妊娠晚期孕妇 5 6例相比较。结果 :妊娠高血压综合征孕妇伴有明显蛋白尿 (>10 0 0mg/ 2 4hr)者血浆阴离子间隙降低 ,与低钠血症和尿蛋白量及其低白蛋白血症有关 ,而和平均动脉压无相关性。结论 :血浆阴离子间隙测定简单方便 ,实用性强 ,在妊娠期加强对阴离子间隙的监测有助于妊娠高血压综合征的诊断和鉴别诊断 ,并对了解妊娠高血压综合征的严重程度和识别可能存在的酸碱平衡紊乱有一定价值。

Objective:To determine whether pregnancy-induced hypertension syndrome (PIH) is associated with anion gap changes. Methods:Retrospective date were collected from 128 patients with PIH and according to the urine protein amount three subgroups were divided. Results:A low anion gap relative to women with normal pregnancy was found in the groups of PIH patients who had the proteinuria more than 1?000mg/24hr. The anion gap correlated with hyponatremia and proteinuria related plasma albumin level. Conclusions:Monitoring serum anion gap is a valuable index in PIH diagnosis and differentiation.