无症状性脑梗死的临床神经心理学研究

Neuropsychological study on silent brain infarction

目的探讨无症状性脑梗死 (SBI)患者的神经心理改变以及引起SBI认知障碍的危险因素。方法对 3 6例SBI和 2 5例正常被试者进行多种神经心理测验及对照分析 ,对认知损害的危险因素进行多元logistic回归分析。 结果SBI组的视觉保持测验成绩和韦氏智力量表的总智商、知觉组织因子和记忆 /注意因子标准分显著低于正常组 ,抑郁量表 (SDS)分高于正常组。logistic回归选入高血压病史、合并脑白质疏松进入模型。结论SBI神经心理损害表现为一定程度的视 -空能力缺陷、知觉组织和记忆及注意力障碍和抑郁。

ObjectiveTo investigate the neuropsychological impairments and risk factors that caused cognitive disturbance in patients with silent brain infarction (SBI). Methods36 SBI subjects and 25 normal controls were compared on a comprehensive neuropsychological test battery. Logistic regression was used to analysis the risk factors. ResultsThe SBI group scored lower on the visual retention test (VRT), the WAIS RC full scale IQ, standard scores of the perceptual organization factor and memory/attention factors than did the control group. The score of self rating depression scale (SDS) was higher in SBI group. Hypertension and leukoaraiosis (LA) were correlates of cognitive impairment in logistic regression analyses. Conclusions SBI has some degree of neuropsychological impairment, especially deficits of visuospatial ability, disturbance of perceptual organization, memory and attention, and some degree of depression. Hypertension and LA independently contribute to the risk factors of cognitive disturbance.