摘要
利用大鼠离体心钙反常模型,探索山莨菪碱抗再灌心律失常的机制。在稳定期和无钙期,用山莨菪碱3.28×10^(-4)mol/L能降低复钙初期心律失常发生率(p<0.05),减轻线粒体钙沉积;如仅在复钙期给药,虽可改善复钙期冠脉流量及减少LDH的释放量,但心律失常率仍无改善。说明山莨菪碱抗钙矛盾时的心律失常与阻止复钙期钙离子大量内流有关。
Drug effect of anisodamine in reducing the incidence of arrhythmias of the calcium paradox isolated rat hearts was observed. Fifty fwo male Wistar rat isolated hearts were randomly divided into: 1) blank control group (N=10) , 2) calcium paradox control group (N = 22), and 3) amisodamime calcium paradox group A (N=11), in which anisodamine (3. 28 ×10-4mol/L) , was added in to perfusate during the stable and calcium-depletion phase, and 4) anisodamine calcium paradox group B (N = 9), only the calcium-repletion phase used anisodamine. Epicardial ECG, LDH in coronary effluent and energy eispersive X-ray spectrum identified histocytochemical utrastructrual distribution of calcium were assayed. Incidence of arrhythmias, mitochondrial calcium deposition, and LDH released in the coronary effluent 1st mih of calcium-repletion phase all decreased significantly in the group A but not in the group B as compaired with the calcium paradox contorl group. Correlation between the arrhthmias and calcium influx that was inhibited by anisodamine when existedl.
出处
《湖南医科大学学报》
CSCD
1989年第2期103-106,共4页
Bulletin of Hunan Medical University
基金
国家自然科学基金
关键词
山莨菪碱
心律失常
钙拮抗剂
anisodamine
calcium channal blockaders
heart
lactic dehydrogenase
arrhythmias
mitochondria
pathophysiology
rat
