脂质过氧化与冠状动脉粥样硬化性心脏病

RELATIONSHIP BETWEEN LIPID PEROXIDATION AND CORONARY HEART DISEASE

对31名心绞痛或陈旧性心肌梗塞的男性冠心病患者及42名健康男性进行血液检测,冠心病患者的血清过氧化脂质(LPO) 含量较健康者显著增高,而血铜,锌,硒含量及谷胱甘肽过氧化物酶(GSH—Px) 和超氧化物岐化酶(SOD) 活力均较健康者显著降低。多因素分析结果,冠心病患者血LPO与GSH-Px,SOD及硒均呈负相关;血硒含量与GSH-Px活力及血铜含量与SOD活力均呈正相关。脂质过氧化增强在冠心病的发生发展过程中可能起着重要的促进作用。

Serum lipoperoxide ( LPO) , blood Cu, Zn, Se, glutathione peroxidase (GSH-Px) activity and erythrocyte superoxide dismutase (SOD) activity were determined in 31 male patients with angina pectoris or healed myocardial infarction (coronary heart disease, CHD group) and 42 male healthy subjects (control group). The results indicated that there was statistically significant increase of LPO, and statistically significant decreases of Cu, Zn, Se , GSH-Px and SOD activities in CHD group as compared with control group.The stepwise regression analysis showed that (1) in control group, there was a negative correlation between LPO and GSH-Px and SOD activities, and a positive correlation between LPO and Cu; (2) in the patients with CHD, a negative correlation between LPO and GSH-Px, SOD activities and Se; (3) positive correlations between Se and GSH-Px activity ( r = 0. 609, P < 0. 01) , and between Cu and SOD activity (r = 0.360, P <0.05) in CHD group.These findings implicate that lipid peroxidation may play an important role in occurrence and development of CHD, and that blood Cu, Zn, and Se may be responsible for alteration of antioxidative function in human body.