腹水纤维连接素鉴别良、恶性腹水

ASSAY OF FIBRONECTIN CONCENTRATION IN ASCITES IN DIFFERENTIATING MALIGNANT FROM NONMALIGNANT ASCITES

测定62例良、恶性腹水病人的腹水纤维连接素(Fn)、胆固醇(Ch)及总蛋白(TP)浓度,恶性腹水组Fn和Ch浓度明显高于良性腹水组(P<0.01)。以Fn浓度80μg/ml及胆固醇浓度1.036mmol/L作为鉴别良、恶性腹水的临界值,判断符合率分别为85.5％和77.4％,提示检测腹水Fn浓度可用于鉴别诊断良、恶性腹水。

The fibronection (Fn), Cholesterol (Ch) and total protein (Tp) concentration of ascites in 62 patients with malignant or nonmalignant ascites were assayed. The results suggested that both Fn and Ch concentration in malignant ascites group were significantly higher than those of nonmalignant group (P< 0.01) .When a cutoff concentration of either Fn (80μg/ml) or Ch (1.036mmol/L) was set up, the accuracy of differential diagnosis in two groups of ascites ran as high as 85.5% (Fn) and 77.4% (Ch) respectively.It indicates that to measure the Fn concentration of ascites can be regarded as an important supplementary index in differentiating malignant from nonmalignant ascites.