高原移居者脑-体工作能力的药物干预初步观察

Effect of Tyrosine and Acetazolamide on Brain-Body Function of Healthy Youth on High Attitude

目的 :应用心理生理能力功效学的方法 ,观察口服酪氨酸和乙酰唑胺提高和改善高原移居者低氧条件下脑 -体工作能力的作用。方法 :选择进驻西喀喇昆仑山海拔 3 70 0m 6个月的某部男性青年 3 0名 ,分别给予口服酪氨酸 (B组 10人 ) ,乙酰唑胺 (C组 10人 ) ,自制炒面胶囊 (A组、对照组 10人 )。实施 15天 ,服药前后应用自行车功量仪进行达负荷指标 (W2 2 5 -2 5 0、P175 -180 /分 )的运动 ,采用DDX -2 0 0型电脑多功能心理生理能力测试仪 ,在服药前运动后 ,服药 15天后运动后和停药 10天后运动后三个阶段 ,进行左右上下肢交叉动作频率与光信号视觉记忆测验 ,对三个阶段A、B、C组的测验结果进行对比。结果 :服药前运动后肢体运动与视觉记忆A、B、C组测验结果交叉对比无差异 (P >0 0 5 ) ;服药 15天运动后与服药前运动后A、B、C组比较 ,B、C组右手左脚及左手右脚交叉动作频率总次数 ,正确次数及右手左脚交叉动作频率错误次数显著增多 (P <0 0 1或P <0 0 5 )。左手右脚交叉动作频率错误次数显著减少 (P <0 0 1或P<0 0 5 )。视觉记忆错误次数显著减少 (P <0 0 1) ;服药 15天运动后与停药 10天运动后A、B、C组比较 ,B、C组右手左脚和左手右脚交叉动作频率总次数、正确次数显著增多 (P <0 0 1或P <0 0 5 )?

Objective:To study the effect of tyrosine and acetazolamide on brain-body function of healthy youth on high attitude Method:30 male subjects having stayed 3700m attitude for 6 months were randomly allocated into three groups: tyrosine group, acetazolamide group and control group Their hands-feet cross movement and light-signal memory were tested with DDX-200 multifunction machine at rest and after incremental exercise before taking medicine, after taking for 15 days, and 10 days after the medicine was stopped Results:The total times, correct times and wrong times of cross-movement increased after taking medicines for 15 days both at rest and after exercise, the wrong times in vision-memory test decreased, all of the effect retained for 10 days after stopping the medications Conclusion:Both tyrosine and acetazolamide can improve the brain-body function at high attitude and these effects maintained for 10 days after stopping the medicines