513例住院精神分裂症患者临床特点的性别差异

Gender Difference of Clinical Features of Schizophrenia

目的 :比较男性及女性精神分裂症住院病人的起病年龄、症状特点、病程演变特点及社会功能等指标的差异。方法 :选择 5 13例住院精神分裂症患者 ,详细收集临床资料 ,并进行《阳性及阴性症状评定量表》 (PANSS)及《大体功能量表》 (GAF)的评定 ,以此为依据进行性别间的比较分析。结果 :(1)总体上看 ,男性患者的起病年龄 (2 5 6± 7 3岁 )显著早于女性患者 (2 7 5± 8 6yrs) (P <0 0 1) ,但有家族史的患者间起病年龄差异不显著 (2 6 3± 6 9岁vs 2 6 8± 8 4岁 ) ;与男性相比 ,女性患者具有如下倾向 :症状模式较多为持续阳性症状 ,多为发作性波动或轻度恶化病程 ,阳性及情感症状更明显 ,且未婚或离婚的比例(5 3 9% )显著低于男性 (67 2 % )。结论 :男性及女性精神分裂症患者在发病年龄、症状特点及病程转归等多方面均存在显著差异 ,提示在制定治疗康复方案方面 。

Objective: To investigate the gender differences of age of onset, clinical symptoms, course pattern and social function between male and female schizophrenic patients Method:513 inpatients with schizophrenia (according to CCMD-2-R criteria, male 288, and female 255) were sampled Clinical data were collected with PANSS (positive and negative symptom scale) Results:The average age of onset in male was 26(7 yrs, that in female was 28±9 yrs, the difference in between had statistical significance The difference of age of onset between male and female patients with positive family history was not significant in statistic Compared with male, female had more positive symptoms and affective symptoms, their course manifested as fluctuating, episodic and deteriorate slightly More male (67%) than female (54%) lived alone (had never marry or divorced) Conclusion:Schizophrenic inpatients had some differences in clinical features, which may due to the nature selection of admission