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五配位磷化合物与生物化学 被引量：2

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摘要 综述了五配位磷化合物与生物化学的关系,发现当α-氨基酸的氨基接上磷酰基团以后,化学性质发生了许多奇特的现象,在室温下可发生自身活化现象而成肽、成酯、磷上酯交换及N→O磷酰基转位;丝氨酸和苏氨酸与核苷缀合以后,在弱碱性条件下能够对不同的碱基进行识别;磷酰化组氨酸和丝组二肽可以在中性条件下切割核酸、蛋白、酯.发现上述现象的发生都经历了一个五配位磷中间体,认为五配位磷中间体是决定它们活性的结构因素.
作者 林长学 李艳梅 成昌梅 韩波 万荣 赵玉芬 冯亚兵
机构地区 生命有机磷化学教育部重点实验室 厦门大学化学系
出处 《中国科学（B辑）》 CSCD 北大核心 2002年第3期193-203,共11页 Science in China(Series B)
基金 国家自然科学基金资助项目(批准号:20132020 20175026)
关键词 五配位磷化合物 生物化学 核苷酸 氨基酸 生命起源 生物活性 仿生化反应
分类号 O641.4 [理学—物理化学]
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  • 1[1]Joyce G F. RNA evolution and origins of life. Nature, 1989, 338: 217～224
  • 2[2]Dickerson R E. Chemical evolution and the origin of life. Sci Amer, 1978, 239(3): 70～86
  • 3[3]Orgel L E. The origin of life on the earth. Sci Amer, 1994, 271(4): 76～83
  • 4[4]Westheimer F H. Why nature chose phosphates. Science, 1987, 235(4793): 1173～1178
  • 5[5]Todd L. Where There's Life, There's Phosphorus. In: Makoto K, Keiko N, Tairo O, eds. Science and Scientists. Tokyo: Japan Sci Soc Press, 1981. 275～279
  • 6[6]Weckwerth G , Schidlowski M. Phosphorus as a potential guide in the search for extinct life on mars. Adv Space Res, 1995, 15(3): 185～191
  • 7[7]Nelson L D, Cox M M. Lehninger Principles of Biochemistry (Edition III). Worth Publishers Inc, 1993. 652～658
  • 8[8]van Ool Peter J J M, Buck H M. A quantum-chemical model description for the function of cyclic AMP. Its degradation and activation of protein kinase. Recl Tranv Chim Pays-Bas, 1981, 100: 79～80
  • 9[9]van Ool Peter J J M, Buck H M. The mechanisms of action of cAMP: A quantum chemical study. Eur J Biochem, 1981, 121(2): 329～334
  • 10[10]Blatter W A, Knowles J R. Stereochemical course of glycerol kinase, pyruvate kinase, and hexokinase: Phosphoryl transfer from chiral[g(s)-16O,17O,18O]ATP. J Am Chem Soc, 1979, 101: 510～511

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  • 1COTRELL P L, GABBIANELLI A, REIERSON R L. Aqueous surfaetant compositions of monoalkyl phosphate ester salts and amphoterie surfactants: US, 6 566 408 [ P]. 2003-05-20.
  • 2STAWINSKI J, KRASZWSKI A. How tO get the most out of two phosphorus chemistries: studies on H-phosphonates[J]. Acc. Chem. Res. ,2002,35(11) :952-960.
  • 3BARKER R, OLSEN K W, SHAPER J H, et al. Agarose derivatives of uridine diphosphate and N-acetylglucosamine for the purification of a galactosyltransferase [J ]. J. Biol. Chem. ,1972,247(22):7 135-7 147.
  • 4SAKAKURA A, KATSUKAWA M, ISHIHARA K, et al. Selective synthesis of phosphate monoesters by dehydrativc condensation of phosphoric acid and alcohols promoted by nucleophilie bases[J]. Org. Lett. ,2005,7(10) :1 999-2 000.
  • 5SAKAKURA A, KATSUKAWA orhcnium ( Ⅶ )-catalyzed direct M, ISHIHARA K. The oxcondensation, of phosphoric acid with an alcohol [ J ]. Angew. Chem. Int. Ed., 2007,46 (9) : 1 423-1 426.
  • 6CRANE C M, KAISER J, RAMSDEN N L, et al. Fluorescent inhibitors for IspF, an enzyme in the non-mevalonate pathway for isoprenoid biosynthesis and a potential target for antimalarial therapy [ J ]. Angew. Chem. Int . Ed., 2006,45 (7) : 1 069-1 074.
  • 7CUSHMAN M, SAMBAIAH T, JIN G, et al. Design, synthesis, and evaluation of 9- D-ribityl-amino- 1,3,7,9-tetrahydro- 2, 6, 8-purinetriones beating alkyl phosphate and,-difluorophosphonate substituents as inhibitors of riboflavin synthase and lumazine synthase [ J ]. J. Org. Chem. , 2004,69 (3) : 601-612.
  • 8MANFREDINI S, BARALDI P G, DURINI E, et al.5'-Phosphoramidates and 5'-diphosphates of 2'- O-allyl- D-arabinofuranosyl-uracil, - cytosine, and -adenine : inhibition of ribonucleotide reductase [ J ]. J. ged . Chem. , 1999,42 (17) : 3 243-3 250.
  • 9KAWATE T, ALLERSON C R, WOLFE J L. Regioselective syntheses of 7-nitro-7-deazapurine nucleosides and nucleotides for efficient PCR incorporation [ J ]. Org. Lett., 2005,7(18) :3 865-3 868.
  • 10KOPPISCH A T, BLAGG B S J, POULTER C D. Synthesis of 2- C-methyl- D-erythritol 4-phosphate : the first pathwayspe cific intermediate in the methylerythritol phosphate route to isoprenoids[ J]. Org. Lett. ,2000,2(2) :215-217.

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中国科学（B辑）
2002年 第3期

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