骨化三醇对腹透患者钙磷代谢及T淋巴细胞亚群的影响

Influence of calcitriol on calcium phosphorus metabolism and T lymphocyte subpopulation in peritoneal dialysis patients

目的 :了解骨化三醇 (1 ,2 5 (OH) 2 D3 ,罗钙全 )对腹膜透析患者钙磷代谢及免疫功能的影晌。方法 :观察 3 7例腹膜透析 (PD)患者服用骨化三醇前后血清T细胞亚群、IL 8以及血免疫反应甲状旁腺激素 (iPTH)、钙、磷水平变化。结果 :用药前PD组血清T淋巴亚群的CD4/CD8低于正常对照组 (P<0 .0 5 ) ,服用骨化三醇 4wk后 ,CD4/CD8从 0 .5 6±0 .1 0升至 0 .79± 0 .1 2 ;而iPTH显著降低 ,血钙显著升高 ,血磷明显下降。结论 :骨化三醇能改善PD患者钙磷代谢 。

AIM: To observe the influence of calcitriol (1,25 (OH) 2D 3) on calcium phosphorus metabolism and immunologic function of peritoneal dialysis (PD) patients. METHODS: The level of serum T cell subpopulation, IL 8, immunoreactive parathyroid hormone(iPTH), calcium, and phosphorus were observed before and after patients taking calcitriol. RESULTS: Before taking medicine, CD4/CD8 of group PD was lower than that of normal comparing group (P< 0.05 ); 4 weeks after taking calcitriol, CD4/CD8 rised from 0.56 ± 0.10 to 0.79 ± 0.12 , and iPTH clearly reduces, while blood calcium, and blood phosphorus obviously goes down as well. CONCLUSION: Calcitriol is able to improve the calcium phosphorus metabolism of PD patients, and their immunologic function.