摘要
甘草是一味重要的传统中药,为临床广泛使用。多年来国内外学者对其化学成分的研究颇为重视。近来,用不同溶剂对甘草进行分步提取,以酶和受体生物学指标进行监测,发现乌拉尔甘草(Glycyrrhiza uralensis Fisch)的二氯甲烷提取物对安定受体,胆囊收缩素受体以及二氢还原酶具有明显的抑制作用。为了寻找其中的有效成分。
This paper reports the isolation and identification of eight crystalline substances (Ⅰ, Ⅱ, Ⅲ, Ⅳ, Ⅴ, Ⅵ, Ⅶ, Ⅷ) from the root of Glycyrrhiza uralensis Fisch. Besides the known compounds liquiritin, hexacosance, β-sitosterol, licoricone liquiritigenin and etc, a new constituent, named neoglycyrol was obtained by sillica gel and polyamide column chromatographic method. Its chemical structure was elucidated by means of chemical and spectrometric analysis (UV, IR, NMR and MS).Neoglycyrol, C_(21)H_(18)O_6, yellow needles with mp 263.5～265℃, possesses one methoxyl, one isopentenyl and two hydroxyls. Its diacetate derivative is C_(25)H_(22)O_8 with mp202～203.5℃. Its dimethyl ether derivative is C_(23)H_(22)O_6 with mp 207～208.5℃ Its structure was found to be Ⅶ.
出处
《药学学报》
CAS
CSCD
北大核心
1991年第2期147-151,共5页
Acta Pharmaceutica Sinica
关键词
乌拉尔甘草
香豆素
新甘草酚
Glycyrrhiza uralensis Fisch
Coumarin
Neoglycyrol
