医学生感觉寻求特征与血小板单胺氧化酶活性之间的关系

The relationship between sensation seeking and monoamine oxidase activity in medical students

目的 :医学生感觉寻求与MMPI及单胺氧化酶活性关系的探讨。方法 :以 79名三、四年级医科大学学生为研究对象 ,进行MMPI、感觉寻求及泽克曼 -库赫曼人格问卷测试 ,同时测定血小板MAO活性。结果 :①感觉寻求总分、兴奋与冒险寻求得分、经验寻求得分、冲动性感觉寻求得分均与MMPI中的抑郁项得分呈负相关 (r =- 0 .349,P =0 .0 0 2 ) (r =- 0 .2 3,P =0 .0 4 2 ) (r =- 0 .4 31,P =0 .0 0 0 ) (r =- 0 .2 35 ,P =0 .0 0 3) ;放纵欲望与MMPI中的轻躁狂项得分呈正相关 (r=0 .2 37,P =0 .0 35 )。②冲动性感觉寻求得分与血小板MAO活性呈显著负相关 (r =- 0 .339,P=0 .0 0 9)。结论 :医学生感觉寻求特征与MMPI抑郁呈负相关 ,与轻躁狂呈显著正相关 ;

Objective: To study relationship of sensation seeking and MMPI personality and monoamine oxidase activity in medical students. Method: 79 medical students were invastigated with MMPI, Sensation seeking scale (SSS) and Zuckerman-Kuhlman's personality inventory (ZKPQ) ,and platelet MAO activity was measured at the same time. Results: 1. Total sensation seeking score?Thrill and adventure seeking score?Experience seeking score?Impulsive sensation seeking score were negatively correlated to depression score in MMPI (r=-0.349,P=0.002)(r=-0.23,P=0.042)(r=-0.431,P=0.000)(r=-0.235,P=0.003) ; Disinhibition score is positively correlated to hypomania score in MMPI (0.237,P=0.035) ;2. Impulsive sensation seeking score is negatively correlated to platelet monoamine oxidase activity. Conclusions: The trait of sensation seeking is related to depression?hypomania in MMPI; platelet monoamine oxidase activity can be treated as a stable biological marker which is related to the impulsivity-sensation seeking trait.