摘要
麻黄碱在受热时可挥发,在蒸除提取溶剂时相随挥发损失,不能用常规的提取重量法测定。使用本室新近研制的涂圈压电传感器作为超微量质量敏感元件,取常规提取重量法的基本原理,并加以改进,可以实现麻黄碱的快速分析,从而扩大该经典方法的应用范围。本法可测定低至亚μg级的麻黄碱,具有方法简便、灵敏度高等优点。
A new extraction - frequencymetric method has been proposed for the determination of ephedrine, which can not be determined by the conventional extraction - weighing method due to its volatility. The method is based on extraction of the free alkaloid followed by measuring the frequency shift of a specially constructed ring- coated piezoelectric crystal at room temperature. The frequency shift is in linear relationship with the content of ephedrine hydrochloride over a range 0.05 - 1.2 μg with a correlation coefficient of 0.999 and a detection limit of 0.02μg. Methods for the assay of ephedrine hydrochloride tablet and nasal solution have been proposed.
出处
《药学学报》
CAS
CSCD
北大核心
1991年第4期311-314,共4页
Acta Pharmaceutica Sinica
基金
国家自然科学基金
国家教委博士点基金
关键词
麻黄碱
药物分析
Extraction-frequencymetric method
Piezoelectric detector
Ephedrine
