黄甘草皂甙的结构

THE STRUCTURE OF GLYEURYSAPONIN

本文报道自黄甘草(Glycyrrhiza eurycarpa P.C.Li)根茎中获得两个皂甙化合物K-3和K-4。根据理化性质和光谱数据鉴定K-4为3-β-羟基-11-氧化-齐墩果-12-烯-30-羧酸-3-O-β-D-吡喃葡萄糖醛酸基(1→4)-β-D-吡喃葡萄糖醛酸甙,为一新的天然产物,命名为黄甘草皂甙(glyeurysaponin)。K-3为已知皂甙乌拉尔甘草皂甙乙(uralsaponin B)。二者均为首次从该种植物中获得。本文报道化合物K-4的结构鉴定。

A species of the genus Glycyrrhiza, G. eurycarpa P. C. Li recently reported as a new species growing in Gansu Province and Xinjiang Autonomous Region has rarely been studied before on its chemical constituents. This paper reports the isolation and chemical elucidation of two triterpene glucosides named glyeurysaponin (K-4) and uralsaponin B (K-3)from this species collected in Jinta County, Gansu Province. Their chemical structures were elucidated by means of chemical and spectrometric analysis (UV, IR, MS, ~1HNMR and ^(13)CNMR)and were first reported to be present in this plant. Glyeurysaponin (K-4), C_(42)H_(62)O_(16) was obtained as white crystals, mp 288℃ (d),[α]_D^(18)+22.5°(c 0.62, 60% MeOH ). Its structure was found to be 3β- hydroxy- 11 - oxo- olean - 12 - en - 30 - oic acid - 3 - O -β- D - glucuronopyranosyl - (1→4 )-β- D -glucuronopyranoside. Glyeurysaponin is a new triterpenoid saponin. The known saponin was identified to be 3β- hydroxy- 11 - oxo- olean- 12- en - 30- oic acid - 3 - O -β- D - glucuronopyranosyl - (1→ 3 ) -β- D- glucuronopyranoside, uralsaponin B.