摘要
本文应用气相色谱技术直接测定三种生物膜(人红细胞膜,人血小板膜和鼠肝线粒体膜)多不饱和脂肪酸的含量变化,检测脂质过氧化程度。实验证实几种多羟酚类化合物(儿茶精,阿魏酸钠和没食子酸及其衍生物)不同程度地抑制(OH)诱导的脂质过氧化反应,并呈量效和构效关系。这类抗氧化剂对保护生物膜的结构与功能是有益的。
A gas chromatography method for the determination of degree of lipid peroxidation of polyunsaturated fatty acids(PUFA) in 3 kinds of biomembrane (human red blood cell, human platelet membrane and mitochondrial membrane of rat liver)was established. The method was used to study the inhibiting effect of several antioxidants on OH~· radical induced lipid peroxidation reaction in biomembrane. The results showed that several compounds with phenolic hydroxyl groups (catechuicine, sodium ferulate, gallic acid and its derivatives ) have significant protective effect on PUFA of the 3 kinds of biomembrane.
出处
《药学学报》
CAS
CSCD
北大核心
1991年第6期406-410,共5页
Acta Pharmaceutica Sinica
基金
国家自然科学基金(3880903)
关键词
气相色谱
抗氧化剂
生物膜
脂肪酸
Gas chromatography
Antioxidants
Biomembrane
Lipid peroxidation
